Escherichia coli
prsA
Sequence
GTGCCTGATATGAAGCTTTTTGCTGGTAACGCCACCCCGGAACTAGCACAACGTATTGCCAACCGCCTGTACACTTCACTCGGCGACGCCGCTGTAGGTCGCTTTAGCGATGGCGAAGTCAGCGTACAAATTAATGAAAATGTACGCGGTGGTGATATTTTCATCATCCAGTCCACTTGTGCCCCTACTAACGACAACCTGATGGAATTAGTCGTTATGGTTGATGCCCTGCGTCGTGCTTCCGCAGGTCGTATCACCGCTGTTATCCCCTACTTTGGCTATGCGCGCCAGGACCGTCGCGTCCGTTCCGCTCGTGTACCAATCACTGCGAAAGTGGTTGCAGACTTCCTCTCCAGCGTCGGTGTTGACCGTGTGCTGACAGTGGATCTGCACGCTGAACAGATTCAGGGTTTCTTCGACGTTCCGGTTGATAACGTATTTGGTAGCCCGATCCTGCTGGAAGACATGCTGCAGCTGAATCTGGATAACCCAATTGTGGTTTCTCCGGACATCGGCGGCGTTGTGCGTGCCCGCGCTATCGCTAAGCTGCTGAACGATACCGATATGGCAATCATCGACAAACGTCGTCCGCGTGCGAACGTTTCACAGGTGATGCATATCATCGGTGACGTTGCAGGTCGTGACTGCGTACTGGTCGATGATATGATCGACACTGGCGGTACGCTGTGTAAAGCTGCTGAAGCTCTGAAAGAACGTGGTGCTAAACGTGTATTTGCGTACGCGACTCACCCGATCTTCTCTGGCAACGCGGCGAACAACCTGCGTAACTCTGTAATTGATGAAGTCGTTGTCTGCGATACCATTCCGCTGAGCGATGAAATCAAATCACTGCCGAACGTGCGTACTCTGACCCTGTCAGGTATGCTGGCCGAAGCGATTCGTCGTATCAGCAACGAAGAATCGATCTCTGCCATGTTCGAACACTAA
Phosphoribosyl pyrophosphate synthetase (Prs) is subject to feedback inhibition by Mg-ADP, which reflects reduced cellular energy status and suppresses PRPP synthesis; to mitigate this regulation in metabolic engineering, the prsD128A allele is introduced, encoding a feedback-insensitive enzyme variant [341].
| Gene size: | |
| Protein size: | |
| Reactions | R115 |
| Compounds affected | xanthine , uridine , IMP , hypoxanthine , L-tryptophan , β-nicotinamide D-ribonucleotide , L-histidine and riboflavin |
Databases
| EraGene: | 2111904 |
|---|---|
| UniProt: | P0A717 |