Escherichia coli
ldhA
Sequence
ATGAAACTCGCCGTTTATAGCACAAAACAGTACGACAAGAAGTACCTGCAACAGGTGAACGAGTCCTTTGGCTTTGAGCTGGAATTTTTTGACTTTCTGCTGACGGAAAAAACCGCTAAAACTGCCAATGGCTGCGAAGCGGTATGTATTTTCGTAAACGATGACGGCAGCCGCCCGGTGCTGGAAGAGCTGAAAAAGCACGGCGTTAAATATATCGCCCTGCGCTGTGCCGGTTTCAATAACGTCGACCTTGACGCGGCAAAAGAACTGGGGCTGAAAGTAGTCCGTGTTCCAGCCTATGATCCAGAGGCCGTTGCTGAACACGCCATCGGTATGATGATGACGCTGAACCGCCGTATTCACCGCGCGTATCAGCGTACCCGTGATGCTAACTTCTCTCTGGAAGGTCTGACCGGCTTTACTATGTATGGCAAAACGGCAGGCGTTATCGGTACCGGTAAAATCGGTGTGGCGATGCTGCGCATTCTGAAAGGTTTTGGTATGCGTCTGCTGGCGTTCGATCCGTATCCAAGTGCAGCGGCGCTGGAACTCGGTGTGGAGTATGTCGATCTGCCAACCCTGTTCTCTGAATCAGACGTTATCTCTCTGCACTGCCCGCTGACACCGGAAAACTATCATCTGTTGAACGAAGCCGCCTTCGAACAGATGAAAAATGGCGTGATGATCGTCAATACCAGTCGCGGTGCATTGATTGATTCTCAGGCAGCAATTGAAGCGCTGAAAAATCAGAAAATTGGTTCGTTGGGTATGGACGTGTATGAGAACGAACGCGATCTATTCTTTGAAGATAAATCCAACGACGTGATCCAGGATGACGTATTCCGTCGCCTGTCTGCCTGCCACAACGTGCTGTTTACCGGGCACCAGGCATTCCTGACAGCAGAAGCTCTGACCAGTATTTCTCAGACTACGCTGCAAAACTTAAGCAATCTGGAAAAAGGCGAAACCTGCCCGAACGAACTGGTTTAA
The ldhA gene encodes lactate dehydrogenase, which catalyzes lactate formation and native NAD⁺ regeneration; its deletion removes competing fermentative pathways and enables alternative metabolites, such as butyrate, to function as final electron acceptors [353].
| Gene size: | |
| Protein size: | |
| Reactions | R504 |
| Compounds affected | trans-aconitate , (S)-malate , (-)-patchoulol , succinate , L-aspartate , (R,R)-2,3-butanediol , L-leucine , L-tyrosine , glycolate , ectoine , L-homoserine , (R)-pantothenate , N-acetyl-L-glutamate , 3-methyl-2-oxobutanoate , L-alanine , butanoate , 1,5-pentanediol , (4S)-limonene , pyruvate , L-valine , L-arginine , (S)-lactate , β-alanine and isobutanol |
Databases
| EraGene: | 2111308 |
|---|---|
| UniProt: | P52643 |