curcumin
Description
Curcumin is a highly bioactive, hydrophobic polyphenol with low aqueous solubility, primarily extracted from the plant Curcuma longa. It is renowned for its antioxidative, anti-inflammatory, anticarcinogenic, and anti-diabetic properties. In Escherichia coli, curcumin is synthesized heterologously from ferulic acid through the action of enzymes such as 4-coumaroyl CoA ligase and curcuminoid synthase. However, its accumulation can compromise cell membranes by decreasing membrane fluidity. This toxicity can be mitigated by supplementing unsaturated fatty acids or by engineering enhanced membrane storage capacity [349].
Chemical Formula:
C21H20O6
Molecular Weight:
368.385 Daltons
Monoisotopic Mass:
368.12598837459996 Daltons
SMILES:
COC2(C=C(C=CC(=CC(C=CC1(C=C(C(=CC=1)O)OC))=O)O)C=CC(O)=2)
InChI:
1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-13,22,24-25H,1-2H3/b7-3+,8-4+,16-13-
InChIKey:
Synonyms
- diferuloylmethane
Databases
MetaCyc:
CPD-6602
MetaboLights:
MTBLC3962
HMDB:
HMDB02269
ChemSpider:
4445080
ChEBI:
3962
PubChem (CID):
5281767
KEGG:
C10443
Seed:
cpd07329
MetaNetX:
MNXM3954
BiGG:
cur