Silencing
Overexpression
Feedback insensitive
Attenuation
Feed-forward insensitive
Inhibition insensitive
Unstated
Combined modifications

Titer in Flask for L-phenylalanine

Modifications
Strain Maximum production aroGEc aroFEc pheAEc tyrREc tyrAEc trpEEc csrAEc csrDEc csrBEc tktAEc zwfEc ptsHEc ptsIEc crrEc galPEc glkEc ydiBEc aroCEc aroDEc ppsAEc pckEc talBEc
E. coli JM101-fbr 100 mg/L
E. coli PB12-fbr 160 mg/L
E. coli Xllp02 770 mg/L
E. coli Xllp12 1,180 mg/L
E. coli NST37 1,194.87 mg/L
E. coli NST [pTktA] 1,217.11 mg/L
E. coli NST [pZwf] 1,265.75 mg/L
E. coli NSTCSRACSRD 1,415.42 mg/L
E. coli NSTCSRA [pCsrB] 1,521.57 mg/L
E. coli NSTCSRA [pZwf] 1,606 mg/L
E. coli NSTCSRD 1,612.07 mg/L
E. coli NSTCSRA 1,669.84 mg/L
E. coli Xllp15 1,680 mg/L
E. coli Xllp14 1,740 mg/L
E. coli NSTCSRA [pTkaFpA] 1,840 mg/L
E. coli Xllp18 1,860 mg/L
E. coli NST [pCsrB] 2,334.73 mg/L
E. coli NSTCSRA [pTktA] 2,391.5 mg/L
E. coli Xllp09 2,690 mg/L
E. coli Xllp03 2,870 mg/L
E. coli Xllp10 2,980 mg/L
E. coli HD-1 3,060 mg/L
E. coli Xllp06 3,260 mg/L
E. coli Xllp19 3,280 mg/L
E. coli Xllp11 3,340 mg/L
E. coli Xllp05 3,650 mg/L
E. coli Xllp17 3,670 mg/L
E. coli Xllp13 3,690 mg/L
E. coli Xllp04 4,200 mg/L
E. coli Xllp07 4,210 mg/L
E. coli Xllp20 4,770 mg/L
E. coli Xllp23 6,120 mg/L
E. coli Xllp08 6,310 mg/L
E. coli Xllp22 6,430 mg/L
E. coli Xllp21 7,150 mg/L
E. coli Xllp16 7,430 mg/L

Titer in Fed-Batch for L-phenylalanine

Modifications
Strain Maximum production pheAEc aroFEc ptsHEc galPEc glkEc tyrREc aroDEc craEc dadXEc cvrAEc aroEEc xfpkBa ylbEEc pycCg pykFEc dhaLEc pckEc aspAEc mhpAEc adhEEc rpoSEc thrWEc ykfNEc
E. coli HD-1 45,000 mg/L
E. coli Xllp21 72,900 mg/L
E. coli PHE07 74,010 mg/L
E. coli PHE08 77,150 mg/L
E. coli PHE09 80,840 mg/L
E. coli PHE10 88,260 mg/L
E. coli PHE12 92,210 mg/L
E. coli PHE11 94,720 mg/L
E. coli PHE13 101,580 mg/L
E. coli PHE17 103,150 mg/L
E. coli PHE14 105,360 mg/L

Biomass-specific titer in Flask for L-phenylalanine

Modifications
Strain Maximum production aroGEc aroFEc pheAEc tyrREc tyrAEc trpEEc csrAEc csrDEc csrBEc tktAEc zwfEc
E. coli NST37 -999,999,999
E. coli NSTCSRA -999,999,999
E. coli NSTCSRD -999,999,999
E. coli NST [pCsrB] -999,999,999
E. coli NSTCSRA [pCsrB] -999,999,999
E. coli NSTCSRACSRD -999,999,999
E. coli NST [pTktA] -999,999,999
E. coli NST [pZwf] -999,999,999
E. coli NSTCSRA [pTktA] -999,999,999
E. coli NSTCSRA [pZwf] -999,999,999
E. coli NSTCSRA [pTkaFpA] -999,999,999

Substrate yield in Flask for L-phenylalanine

Modifications
Strain Maximum production ptsHEc ptsIEc crrEc aroGEc tktAEc pheAEc aroFEc galPEc glkEc tyrREc ppsAEc pckEc talBEc aroDEc ydiBEc aroCEc
E. coli Xllp02 0.04 g/g of sustrate
E. coli Xllp15 0.04 g/g of sustrate
E. coli Xllp18 0.04 g/g of sustrate
E. coli JM101-fbr 0.05 g/g of sustrate
E. coli Xllp12 0.05 g/g of sustrate
E. coli Xllp14 0.05 g/g of sustrate
E. coli Xllp03 0.06 g/g of sustrate
E. coli Xllp09 0.06 g/g of sustrate
E. coli HD-1 0.07 g/g of sustrate
E. coli Xllp06 0.07 g/g of sustrate
E. coli Xllp10 0.07 g/g of sustrate
E. coli Xllp11 0.07 g/g of sustrate
E. coli Xllp19 0.07 g/g of sustrate
E. coli Xllp05 0.08 g/g of sustrate
E. coli Xllp13 0.08 g/g of sustrate
E. coli Xllp17 0.08 g/g of sustrate
E. coli Xllp04 0.09 g/g of sustrate
E. coli Xllp07 0.09 g/g of sustrate
E. coli Xllp20 0.11 g/g of sustrate
E. coli Xllp08 0.12 g/g of sustrate
E. coli Xllp23 0.13 g/g of sustrate
E. coli PB12-fbr 0.14 g/g of sustrate
E. coli Xllp22 0.14 g/g of sustrate
E. coli Xllp16 0.15 g/g of sustrate
E. coli Xllp21 0.16 g/g of sustrate
E. coli JM101-ev1 0.21 g/g of sustrate
E. coli JM101-ev2 0.22 g/g of sustrate
E. coli PB12-ev2 0.33 g/g of sustrate
E. coli PB12-ev1 0.33 g/g of sustrate

Substrate yield in Fed-Batch for L-phenylalanine

Modifications
Strain Maximum production pheAEc aroFEc ptsHEc galPEc glkEc tyrREc aroDEc craEc dadXEc cvrAEc aroEEc xfpkBa ylbEEc pycCg pykFEc dhaLEc pckEc aspAEc mhpAEc adhEEc rpoSEc thrWEc ykfNEc
E. coli HD-1 0.186 g/g of sustrate
E. coli PHE09 0.206 g/g of sustrate
E. coli PHE07 0.207 g/g of sustrate
E. coli PHE10 0.207 g/g of sustrate
E. coli PHE08 0.208 g/g of sustrate
E. coli PHE11 0.222 g/g of sustrate
E. coli PHE12 0.227 g/g of sustrate
E. coli PHE17 0.229 g/g of sustrate
E. coli PHE13 0.229 g/g of sustrate
E. coli PHE14 0.229 g/g of sustrate
E. coli Xllp21 0.26 g/g of sustrate

Biomass-specific productivity in Flask for L-phenylalanine

Modifications
Strain Maximum production ptsHEc ptsIEc crrEc aroGEc tktAEc pheAEc
E. coli JM101-ev2 36 mg/L/g DCW
E. coli PB12-ev1 38 mg/L/g DCW
E. coli JM101-ev1 38 mg/L/g DCW
E. coli PB12-ev2 40.6 mg/L/g DCW