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H2O + 3-methyl-2-oxobutanoate + acetyl-CoA → coenzyme A + (2S)-2-isopropylmalate + H+ (R440)
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Feedback insensitive
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Overexpression
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(2R,3S)-3-isopropylmalate + NAD+ ↔ (2S)-2-isopropyl-3-oxosuccinate + NADH + H+ (R764)
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(2R,3S)-3-isopropylmalate ↔ H2O + 2-isopropylmaleate (R220)
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(2S)-2-isopropylmalate ↔ H2O + 2-isopropylmaleate (R645)
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pyruvate + H+ → (S)-2-acetolactate + CO2 (R545)
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Overexpression
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Feedback insensitive
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2-oxoglutarate + L-leucine ↔ 4-methyl-2-oxopentanoate + L-glutamate (R378)
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(2R)-2,3-dihydroxy-3-methylbutanoate → H2O + 3-methyl-2-oxobutanoate (R1255)
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(2R)-2,3-dihydroxy-3-methylbutanoate + NADP+ ↔ NADPH + H+ + (S)-2-acetolactate (R1241)
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H2O + L-leucine + ATP → L-leucine + phosphate + ADP (R2187)
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L-leucine + H+ → L-leucine + H+ (R00865)
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L-leucine + Na+ → L-leucine + Na+ (R00851)
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L-leucine + H+ → L-leucine + H+ (R00860)
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NADH + NADP+ + H+ → NADPH + NAD+ + H+ (R427)
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H2O + NAD+ + L-leucine → NADH + 4-methyl-2-oxopentanoate + H+ + ammonium (R2407)
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H2O + pyruvate + ubiquinone-8 → acetate + ubiquinol-8 + CO2 (R4535)
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formate + acetyl-CoA ↔ coenzyme A + pyruvate (R278)
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NAD+ + (R)-lactate ← NADH + pyruvate + H+ (R504)
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coenzyme A + 2-oxoglutarate + NAD+ → NADH + succinyl-CoA + CO2 (R1038)