L-homoserine + succinyl-CoA → coenzyme A + O-succinyl-L-homoserine (R369)
- Feedback insensitive
  - Plasmid
L-methionine + H⁺ ↔ L-methionine + H⁺ (R00426)
- Overexpression
  - Plasmid
H₂O + L-methionine + ATP ↔ L-methionine + phosphate + ADP (R385)
- Silencing
  - Genome
H⁺ + meso-diaminopimelate → L-lysine + CO₂ (R367)
- Silencing
  - Genome
    - Escherichia coli W3110 ΔmetJΔmetIΔlysA/pTrcA*H
    - Escherichia coli W3110 ΔmetJΔmetIΔlysAΔthrB/pTrcA*H
L-homoserine + ATP → O-phospho-L-homoserine + H⁺ + ADP (R153)
- Silencing
  - Genome
    - Escherichia coli W3110 ΔmetJΔmetIΔthrB/pTrcA*H
    - Escherichia coli W3110 ΔmetJΔmetIΔlysAΔthrB/pTrcA*H